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Ankyrin-B reduction enhances Ca spark-mediated SR Ca release promoting cardiac myocyte arrhythmic activity

Ankyrin-B (AnkB) loss-of-function may cause ventricular arrhythmias and sudden cardiac death in humans. Cardiac myocytes from AnkB heterozygous mice (AnkB(+/−)) show reduced expression and altered localization of Na/Ca exchanger (NCX) and Na/K-ATPase (NKA), key players in regulating [Na](i) and [Ca]...

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Main Authors: Camors, Emmanuel, Mohler, Peter J., Bers, Donald M., Despa, Sanda
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348355/
https://ncbi.nlm.nih.gov/pubmed/22406428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2012.02.010
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