Formation of Amyloid-Like Fibrils by Y-Box Binding Protein 1 (YB-1) Is Mediated by Its Cold Shock Domain and Modulated by Disordered Terminal Domains

YB-1, a multifunctional DNA- and RNA-binding nucleocytoplasmic protein, is involved in the majority of DNA- and mRNA-dependent events in the cell. It consists of three structurally different domains: its central cold shock domain has the structure of a β-barrel, while the flanking domains are predic...

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Autors principals: Guryanov, Sergey G., Selivanova, Olga M., Nikulin, Alexey D., Enin, Gennady A., Melnik, Bogdan S., Kretov, Dmitry A., Serdyuk, Igor N., Ovchinnikov, Lev P.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348147/
https://ncbi.nlm.nih.gov/pubmed/22590640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036969
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