B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells

B cells have paradoxical roles in autoimmunity, exerting both pathogenic and protective effects. Pathogenesis may be antibody independent, as B cell depletion therapy (BCDT) leads to amelioration of disease irrespective of autoantibody ablation. However, the mechanisms of pathogenesis are poorly und...

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Detalhes bibliográficos
Main Authors: Barr, Tom A., Shen, Ping, Brown, Sheila, Lampropoulou, Vicky, Roch, Toralf, Lawrie, Sarah, Fan, Boli, O’Connor, Richard A., Anderton, Stephen M., Bar-Or, Amit, Fillatreau, Simon, Gray, David
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348102/
https://ncbi.nlm.nih.gov/pubmed/22547654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111675
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