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Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis

Persistent pain after resolution of clinically appreciable signs of arthritis poses a therapeutic challenge and immunosuppressive therapies do not meet this medical need. To investigate this conversion to persistent pain, we utilized the K/BxN serum transfer arthritis model, which has persistent mec...

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Detalhes bibliográficos
Main Authors: Christianson, Christina A., Dumlao, Darren S., Stokes, Jennifer A., Dennis, Edward A., Svensson, Camilla I., Corr, Maripat, Yaksh, Tony L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347973/
https://ncbi.nlm.nih.gov/pubmed/22019135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2011.09.020
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