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Spindle assembly checkpoint signalling is uncoupled from chromosomal position in mouse oocytes
The spindle assembly checkpoint (SAC) averts aneuploidy by coordinating proper bipolar chromosomal attachment with anaphase-promoting complex/cyclosome (APC/C)-mediated securin and cyclin B1 destruction required for anaphase onset. The generation of a Mad2-based signal at kinetochores is central to...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Company of Biologists
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3347686/ https://ncbi.nlm.nih.gov/pubmed/22513372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.078352 |
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