Widespread Impact of HLA Restriction on Immune Control and Escape Pathways of HIV-1

The promiscuous presentation of epitopes by similar HLA class I alleles holds promise for a universal T-cell-based HIV-1 vaccine. However, in some instances, cytotoxic T lymphocytes (CTL) restricted by HLA alleles with similar or identical binding motifs are known to target epitopes at different fre...

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Autores principales: Carlson, Jonathan M., Listgarten, Jennifer, Pfeifer, Nico, Tan, Vincent, Kadie, Carl, Walker, Bruce D., Ndung'u, Thumbi, Shapiro, Roger, Frater, John, Brumme, Zabrina L., Goulder, Philip J. R., Heckerman, David
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347390/
https://ncbi.nlm.nih.gov/pubmed/22379086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06728-11
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