Preclinical Evaluation of a Genetically Engineered Herpes Simplex Virus Expressing Interleukin-12

Herpes simplex virus 1 (HSV-1) mutants that lack the γ(1)34.5 gene are unable to replicate in the central nervous system but maintain replication competence in dividing cell populations, such as those found in brain tumors. We have previously demonstrated that a γ(1)34.5-deleted HSV-1 expressing mur...

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Detalhes bibliográficos
Main Authors: Markert, James M., Cody, James J., Parker, Jacqueline N., Coleman, Jennifer M., Price, Kathleen H., Kern, Earl R., Quenelle, Debra C., Lakeman, Alfred D., Schoeb, Trenton R., Palmer, Cheryl A., Cartner, Samuel C., Gillespie, G. Yancey, Whitley, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Gene Delivery
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347348/
https://ncbi.nlm.nih.gov/pubmed/22379082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06998-11
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