Preclinical Evaluation of a Genetically Engineered Herpes Simplex Virus Expressing Interleukin-12

Herpes simplex virus 1 (HSV-1) mutants that lack the γ(1)34.5 gene are unable to replicate in the central nervous system but maintain replication competence in dividing cell populations, such as those found in brain tumors. We have previously demonstrated that a γ(1)34.5-deleted HSV-1 expressing mur...

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Main Authors: Markert, James M., Cody, James J., Parker, Jacqueline N., Coleman, Jennifer M., Price, Kathleen H., Kern, Earl R., Quenelle, Debra C., Lakeman, Alfred D., Schoeb, Trenton R., Palmer, Cheryl A., Cartner, Samuel C., Gillespie, G. Yancey, Whitley, Richard J.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2012
主題:
Gene Delivery
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347348/
https://ncbi.nlm.nih.gov/pubmed/22379082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06998-11
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