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A Conserved Tandem Cyclophilin-Binding Site in Hepatitis C Virus Nonstructural Protein 5A Regulates Alisporivir Susceptibility

Cyclophilin A (CyPA) and its peptidyl-prolyl isomerase (PPIase) activity play an essential role in hepatitis C virus (HCV) replication, and mounting evidence indicates that nonstructural protein 5A (NS5A) is the major target of CyPA. However, neither a consensus CyPA-binding motif nor specific proli...

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Detalhes bibliográficos
Main Authors: Grisé, Henry, Frausto, Stephen, Logan, Timothy, Tang, Hengli
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347344/
https://ncbi.nlm.nih.gov/pubmed/22345441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06641-11
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