West Nile Virus Noncoding Subgenomic RNA Contributes to Viral Evasion of the Type I Interferon-Mediated Antiviral Response

We previously showed that a noncoding subgenomic flavivirus RNA (sfRNA) is required for viral pathogenicity, as a mutant West Nile virus (WNV) deficient in sfRNA production replicated poorly in wild-type mice. To investigate the possible immunomodulatory or immune evasive functions of sfRNA, we util...

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Главные авторы: Schuessler, Andrea, Funk, Anneke, Lazear, Helen M., Cooper, Daphne A., Torres, Shessy, Daffis, Stephane, Jha, Babal Kant, Kumagai, Yutaro, Takeuchi, Osamu, Hertzog, Paul, Silverman, Robert, Akira, Shizuo, Barton, David J., Diamond, Michael S., Khromykh, Alexander A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2012
Предметы:
Pathogenesis and Immunity
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347305/
https://ncbi.nlm.nih.gov/pubmed/22379089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00207-12
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