Oxidant-Induced Cell Death and Nrf2-Dependent Antioxidative Response Are Controlled by Fra-1/AP-1

AP-1 (Jun/Fos) transcription factors play key roles in various biological processes, including cell death. Here we report a novel role for Fra-1 in oxidant-induced cell death controlled by modulating antioxidant gene expression. Fra-1-deficient (Fra-1(Δ/Δ)) mouse embryonic fibroblasts (MEFs) and pri...

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Main Authors: Vaz, Michelle, Machireddy, Narsa, Irving, Ashley, Potteti, Haranatha R., Chevalier, Karinne, Kalvakolanu, Dhananjaya, Reddy, Sekhar P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347243/
https://ncbi.nlm.nih.gov/pubmed/22393254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06390-11
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