Dystrophin-compromised sarcoglycan-δ-knockout diaphragm requires full wild-type embryonic stem cell reconstitution for correction

Limb-girdle muscular dystrophy-2F (LGMD-2F) is an incurable degenerative muscle disorder caused by a mutation in the sarcoglycan-δ (SGδ)-encoding gene (SGCD in humans). The lack of SGδ results in the complete disruption of the sarcoglycan complex (SGC) in the skeletal and cardiac muscle within the l...

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Bibliographische Detailangaben
Hauptverfasser: Vitale, Joseph M., Schneider, Joel S., Beck, Amanda J., Zhao, Qingshi, Chang, Corey, Gordan, Richard, Michaels, Jennifer, Bhaumik, Mantu, Fraidenraich, Diego
Format: Artigo
Sprache:Inglês
Veröffentlicht: Company of Biologists 2012
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346830/
https://ncbi.nlm.nih.gov/pubmed/22328522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.100537
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