The F423Y Mutation in the pfmdr2 Gene and Mutations N51I, C59R, and S108N in the pfdhfr Gene Are Independently Associated with Pyrimethamine Resistance in Plasmodium falciparum Isolates

Screening for in vitro susceptibility to pyrimethamine and sequencing of the pfmdr2 and pfdhfr genes were performed in 140 Plasmodium falciparum isolates. The risk of in vitro resistance to pyrimethamine was analyzed with a logistic regression model. The mutation F423Y in pfmdr2 (odds ratio [OR] = 2...

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Detalhes bibliográficos
Main Authors: Briolant, Sébastien, Bogreau, Hervé, Gil, Marine, Bouchiba, Housem, Baret, Eric, Amalvict, Rémy, Rogier, Christophe, Pradines, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346656/
https://ncbi.nlm.nih.gov/pubmed/22314533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05618-11
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