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T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3
Agents that increase intracellular cAMP inhibit the activation and function of T cells and can lead to cell death. Recently, it has been postulated that cAMP inhibits T cell function in large part by acting as a brake on the T cell receptor and costimulatory receptor pathways. Therefore, for full ac...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC33466/ https://ncbi.nlm.nih.gov/pubmed/11371644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.101131098 |
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