Nonribosomal Peptide Synthetase Genes pesL and pes1 Are Essential for Fumigaclavine C Production in Aspergillus fumigatus

The identity of metabolites encoded by the majority of nonribosomal peptide synthetases in the opportunistic pathogen, Aspergillus fumigatus, remains outstanding. We found that the nonribosomal peptide (NRP) synthetases PesL and Pes1 were essential for fumigaclavine C biosynthesis, the end product o...

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Detalhes bibliográficos
Main Authors: O'Hanlon, Karen A., Gallagher, Lorna, Schrettl, Markus, Jöchl, Christoph, Kavanagh, Kevin, Larsen, Thomas O., Doyle, Sean
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Mycology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346476/
https://ncbi.nlm.nih.gov/pubmed/22344643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.07249-11
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