Heparin-Binding Hemagglutinin Induces IFN-γ(+) IL-2(+) IL-17(+) Multifunctional CD4(+) T Cells during Latent but Not Active Tuberculosis Disease

The mycobacterial heparin-binding hemagglutinin (HBHA) protein induces a potent gamma interferon (IFN-γ) response in latent tuberculosis (TB) infection and is a candidate vaccine and diagnostic antigen. We have assessed HBHA-specific intracellular IFN-γ, interleukin-2 (IL-2), and IL-17 production by...

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Detalhes bibliográficos
Main Authors: Loxton, André G., Black, Gillian F., Stanley, Kim, Walzl, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Clinical Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346316/
https://ncbi.nlm.nih.gov/pubmed/22461525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00047-12
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