TDP-43 and FUS RNA-binding Proteins Bind Distinct Sets of Cytoplasmic Messenger RNAs and Differently Regulate Their Post-transcriptional Fate in Motoneuron-like Cells

The RNA-binding proteins TDP-43 and FUS form abnormal cytoplasmic aggregates in affected tissues of patients with amyotrophic lateral sclerosis and frontotemporal lobar dementia. TDP-43 and FUS localize mainly in the nucleus where they regulate pre-mRNA splicing, but they are also involved in mRNA t...

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Detalhes bibliográficos
Main Authors: Colombrita, Claudia, Onesto, Elisa, Megiorni, Francesca, Pizzuti, Antonio, Baralle, Francisco E., Buratti, Emanuele, Silani, Vincenzo, Ratti, Antonia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346140/
https://ncbi.nlm.nih.gov/pubmed/22427648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.333450
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