Transcriptional Regulation of T-type Calcium Channel Ca(V)3.2: BI-DIRECTIONALITY BY EARLY GROWTH RESPONSE 1 (Egr1) AND REPRESSOR ELEMENT 1 (RE-1) PROTEIN -SILENCING TRANSCRIPTION FACTOR (REST)

The pore-forming Ca(2+) channel subunit Ca(V)3.2 mediates a low voltage-activated (T-type) Ca(2+) current (I(CaT)) that contributes pivotally to neuronal and cardiac pacemaker activity. Despite the importance of tightly regulated Ca(V)3.2 levels, the mechanisms regulating its transcriptional dynamic...

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Autores principales: van Loo, Karen M. J., Schaub, Christina, Pernhorst, Katharina, Yaari, Yoel, Beck, Heinz, Schoch, Susanne, Becker, Albert J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Gene Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346130/
https://ncbi.nlm.nih.gov/pubmed/22431737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.310763
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