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Protein Kinase A (PKA) Phosphorylation of Na(+)/K(+)-ATPase Opens Intracellular C-terminal Water Pathway Leading to Third Na(+)-binding site in Molecular Dynamics Simulations
Phosphorylation is one of the major mechanisms for posttranscriptional modification of proteins. The addition of a compact, negatively charged moiety to a protein can significantly change its function and localization by affecting its structure and interaction network. We have used all-atom Molecula...
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| Huvudupphovsmän: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Biochemistry and Molecular Biology
2012
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3346126/ https://ncbi.nlm.nih.gov/pubmed/22433860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.340406 |
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