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Six-transmembrane Topology for Golgi Anti-apoptotic Protein (GAAP) and Bax Inhibitor 1 (BI-1) Provides Model for the Transmembrane Bax Inhibitor-containing Motif (TMBIM) Family

The Golgi anti-apoptotic protein (GAAP) is a hydrophobic Golgi protein that regulates intracellular calcium fluxes and apoptosis. GAAP is highly conserved throughout eukaryotes and some strains of vaccinia virus (VACV) and camelpox virus. Based on sequence, phylogeny, and hydrophobicity, GAAPs were...

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Main Authors: Carrara, Guia, Saraiva, Nuno, Gubser, Caroline, Johnson, Benjamin F., Smith, Geoffrey L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346125/
https://ncbi.nlm.nih.gov/pubmed/22418439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.336149
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