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Transmembrane BAX Inhibitor Motif Containing (TMBIM) Family Proteins Perturbs a trans-Golgi Network Enzyme, Gb3 Synthase, and Reduces Gb3 Biosynthesis

Globotriaosylceramide (Gb3) is a well known receptor for Shiga toxin (Stx), produced by enterohemorrhagic Escherichia coli and Shigella dysenteriae. The expression of Gb3 also affects several diseases, including cancer metastasis and Fabry disease, which prompted us to look for factors involved in i...

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Bibliografiske detaljer
Main Authors: Yamaji, Toshiyuki, Nishikawa, Kiyotaka, Hanada, Kentaro
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975175/
https://ncbi.nlm.nih.gov/pubmed/20837469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.154229
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