Bacterial Acyl-CoA Mutase Specifically Catalyzes Coenzyme B(12)-dependent Isomerization of 2-Hydroxyisobutyryl-CoA and (S)-3-Hydroxybutyryl-CoA

Coenzyme B(12)-dependent acyl-CoA mutases are radical enzymes catalyzing reversible carbon skeleton rearrangements in carboxylic acids. Here, we describe 2-hydroxyisobutyryl-CoA mutase (HCM) found in the bacterium Aquincola tertiaricarbonis as a novel member of the mutase family. HCM specifically ca...

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Detalhes bibliográficos
Main Authors: Yaneva, Nadya, Schuster, Judith, Schäfer, Franziska, Lede, Vera, Przybylski, Denise, Paproth, Torsten, Harms, Hauke, Müller, Roland H., Rohwerder, Thore
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346121/
https://ncbi.nlm.nih.gov/pubmed/22433853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.314690
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