Lens Epithelium-derived Growth Factor/p75 Qualifies as a Target for HIV Gene Therapy in the NSG Mouse Model

Lens epithelium-derived growth factor (LEDGF/p75) is an essential cofactor of HIV integration. Both stable overexpression of the C-terminal part of LEDGF/p75 (LEDGF(325–530)) containing the integrase (IN)-binding domain (IBD) and stable knockdown (KD) of LEDGF/p75 are known to inhibit HIV infection...

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Detalhes bibliográficos
Main Authors: Vets, Sofie, Kimpel, Janine, Volk, Andreas, De Rijck, Jan, Schrijvers, Rik, Verbinnen, Bert, Maes, Wim, Von Laer, Dorothee, Debyser, Zeger, Gijsbers, Rik
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345997/
https://ncbi.nlm.nih.gov/pubmed/22334021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.6
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