Radiation-inducible Immunotherapy for Cancer: Senescent Tumor Cells as a Cancer Vaccine

Radiotherapy offers an effective treatment for advanced cancer but local and distant failures remain a significant challenge. Here, we treated melanoma and pancreatic carcinoma in syngeneic mice with ionizing radiation (IR) combined with the poly(ADP-ribose) polymerase inhibitor (PARPi) veliparib to...

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Bibliographic Details
Main Authors: Meng, Yuru, Efimova, Elena V, Hamzeh, Khaled W, Darga, Thomas E, Mauceri, Helena J., Fu, Yang-Xin, Kron, Stephen J, Weichselbaum, Ralph R
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345982/
https://ncbi.nlm.nih.gov/pubmed/22334019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.19
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