Combining PET biodistribution and equilibrium dialysis assays to assess the free brain concentration and BBB transport of CNS drugs

The passage of drugs in and out of the brain is controlled by the blood–brain barrier (BBB), typically, using either passive diffusion across a concentration gradient or active transport via a protein carrier. In-vitro and preclinical measurements of BBB penetration do not always accurately predict...

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Autors principals: Gunn, Roger N, Summerfield, Scott G, Salinas, Cristian A, Read, Kevin D, Guo, Qi, Searle, Graham E, Parker, Christine A, Jeffrey, Phil, Laruelle, Marc
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345915/
https://ncbi.nlm.nih.gov/pubmed/22274741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.1
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