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Superessential reactions in metabolic networks
The metabolic genotype of an organism can change through loss and acquisition of enzyme-coding genes, while preserving its ability to survive and synthesize biomass in specific environments. This evolutionary plasticity allows pathogens to evolve resistance to antimetabolic drugs by acquiring new me...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3345022/ https://ncbi.nlm.nih.gov/pubmed/22509034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113065109 |
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