Near attack conformers dominate β-phosphoglucomutase complexes where geometry and charge distribution reflect those of substrate

Experimental observations of fluoromagnesate and fluoroaluminate complexes of β-phosphoglucomutase (β-PGM) have demonstrated the importance of charge balance in transition-state stabilization for phosphoryl transfer enzymes. Here, direct observations of ground-state analog complexes of β-PGM involvi...

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Bibliografiset tiedot
Päätekijät: Griffin, Joanna L., Bowler, Matthew W., Baxter, Nicola J., Leigh, Katherine N., Dannatt, Hugh R. W., Hounslow, Andrea M., Blackburn, G. Michael, Webster, Charles Edwin, Cliff, Matthew J., Waltho, Jonathan P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2012
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345020/
https://ncbi.nlm.nih.gov/pubmed/22505741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116855109
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