Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apc(min) mice by inhibiting IL-10 secretion and regulatory T-cell generation

To address the role of Tpl2, a MAP3K8 that regulates innate/adaptive immunity and inflammation, in intestinal tumorigenesis, we crossed a Tpl2 KO allele into the Apc(min/+) genetic background. Here, we show that Apc(min/+)/Tpl2(−/−) mice exhibit a fivefold increase in the number of intestinal adenom...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Serebrennikova, Oksana B., Tsatsanis, Christos, Mao, Changchuin, Gounaris, Elias, Ren, Wenying, Siracusa, Linda D., Eliopoulos, Aristides G., Khazaie, Khashayarsha, Tsichlis, Philip N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344997/
https://ncbi.nlm.nih.gov/pubmed/22451924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115098109
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados