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Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail

Hypercholesterolemia, high serum cholesterol in the form of LDL, is a major risk factor for atherosclerosis. LDL is mostly degraded in the liver after its cellular internalization with the LDL receptor (LDLR). This clathrin-mediated endocytosis depends on the protein autosomal recessive hypercholest...

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Autori principali: Dvir, Hay, Shah, Mehul, Girardi, Enrico, Guo, Lixia, Farquhar, Marilyn G., Zajonc, Dirk M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344954/
https://ncbi.nlm.nih.gov/pubmed/22509010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114128109
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