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Hypoxia-Adaptation Involves Mitochondrial Metabolic Depression and Decreased ROS Leakage

Through long-term laboratory selection, we have generated a Drosophila melanogaster population that tolerates severe, normally lethal, level of hypoxia. This strain lives perpetually under severe hypoxic conditions (4% O(2)). In order to shed light on the mechanisms involved in this adaptation, we s...

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Detalhes bibliográficos
Main Authors: Ali, Sameh S., Hsiao, Mary, Zhao, Huiwen W., Dugan, Laura L., Haddad, Gabriel G., Zhou, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344937/
https://ncbi.nlm.nih.gov/pubmed/22574227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036801
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