Proton-Assisted Amino Acid Transporter PAT1 Complexes with Rag GTPases and Activates TORC1 on Late Endosomal and Lysosomal Membranes

Mammalian Target of Rapamycin Complex 1 (mTORC1) is activated by growth factor-regulated phosphoinositide 3-kinase (PI3K)/Akt/Rheb signalling and extracellular amino acids (AAs) to promote growth and proliferation. These AAs induce translocation of mTOR to late endosomes and lysosomes (LELs), subseq...

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Bibliographic Details
Main Authors: Ögmundsdóttir, Margrét H., Heublein, Sabine, Kazi, Shubana, Reynolds, Bruno, Visvalingam, Shivanthy M., Shaw, Michael K., Goberdhan, Deborah C. I.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344915/
https://ncbi.nlm.nih.gov/pubmed/22574197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036616
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