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Identification of Important Chemical Features of 11β-Hydroxysteroid Dehydrogenase Type1 Inhibitors: Application of Ligand Based Virtual Screening and Density Functional Theory

11β-Hydroxysteroid dehydrogenase type1 (11βHSD1) regulates the conversion from inactive cortisone to active cortisol. Increased cortisol results in diabetes, hence quelling the activity of 11βHSD1 has been thought of as an effective approach for the treatment of diabetes. Quantitative hypotheses wer...

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書誌詳細
主要な著者: Sakkiah, Sugunadevi, Meganathan, Chandrasekaran, Sohn, Young-Sik, Namadevan, Sundaraganesan, Lee, Keun Woo
フォーマット: Artigo
言語:Inglês
出版事項: Molecular Diversity Preservation International (MDPI) 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344271/
https://ncbi.nlm.nih.gov/pubmed/22606035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms13045138
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