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Identification of Important Chemical Features of 11β-Hydroxysteroid Dehydrogenase Type1 Inhibitors: Application of Ligand Based Virtual Screening and Density Functional Theory

11ß-Hydroxysteroid dehydrogenase type1 (11ßHSD1) regulates the conversion from inactive cortisone to active cortisol. Increased cortisol results in diabetes, hence quelling the activity of 11ßHSD1 has been thought of as an effective approach for the treatment of diabetes. Quantitative hypotheses wer...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Keun Woo Lee, Sundaraganesan Namadevan, Young-Sik Sohn, Chandrasekaran Meganathan, Sugunadevi Sakkiah
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: MDPI AG 2012-04-01
श्रृंखला:International Journal of Molecular Sciences
विषय:
ऑनलाइन पहुंच:http://www.mdpi.com/1422-0067/13/4/5138
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