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Identification of Important Chemical Features of 11β-Hydroxysteroid Dehydrogenase Type1 Inhibitors: Application of Ligand Based Virtual Screening and Density Functional Theory

11β-Hydroxysteroid dehydrogenase type1 (11βHSD1) regulates the conversion from inactive cortisone to active cortisol. Increased cortisol results in diabetes, hence quelling the activity of 11βHSD1 has been thought of as an effective approach for the treatment of diabetes. Quantitative hypotheses wer...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sakkiah, Sugunadevi, Meganathan, Chandrasekaran, Sohn, Young-Sik, Namadevan, Sundaraganesan, Lee, Keun Woo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Molecular Diversity Preservation International (MDPI) 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344271/
https://ncbi.nlm.nih.gov/pubmed/22606035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms13045138
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