A non-canonical UBA–UBL interaction forms the linear-ubiquitin-chain assembly complex

HOIL-1L and its binding partner HOIP are essential components of the E3-ligase complex that generates linear ubiquitin (Ub) chains, which are critical regulators of NF-κB activation. Using crystallographic and mutational approaches, we characterize the unexpected structural basis for the specific in...

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Bibliografiske detaljer
Main Authors: Yagi, Hirokazu, Ishimoto, Kazuhiro, Hiromoto, Takeshi, Fujita, Hiroaki, Mizushima, Tsunehiro, Uekusa, Yoshinori, Yagi-Utsumi, Maho, Kurimoto, Eiji, Noda, Masanori, Uchiyama, Susumu, Tokunaga, Fuminori, Iwai, Kazuhiro, Kato, Koichi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Scientific Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343348/
https://ncbi.nlm.nih.gov/pubmed/22430200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.24
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