Ebola virus entry requires the host-programmed recognition of an intracellular receptor

Ebola and Marburg filoviruses cause deadly outbreaks of haemorrhagic fever. Despite considerable efforts, no essential cellular receptors for filovirus entry have been identified. We showed previously that Niemann-Pick C1 (NPC1), a lysosomal cholesterol transporter, is required for filovirus entry....

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Auteurs principaux: Miller, Emily Happy, Obernosterer, Gregor, Raaben, Matthijs, Herbert, Andrew S, Deffieu, Maika S, Krishnan, Anuja, Ndungo, Esther, Sandesara, Rohini G, Carette, Jan E, Kuehne, Ana I, Ruthel, Gordon, Pfeffer, Suzanne R, Dye, John M, Whelan, Sean P, Brummelkamp, Thijn R, Chandran, Kartik
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343336/
https://ncbi.nlm.nih.gov/pubmed/22395071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.53
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