NLK positively regulates Wnt/β-catenin signalling by phosphorylating LEF1 in neural progenitor cells

Nemo-like kinase (NLK/Nlk) is an evolutionarily conserved protein kinase involved in Wnt/β-catenin signalling. However, the roles of NLK in Wnt/β-catenin signalling in vertebrates remain unclear. Here, we show that inhibition of Nlk2 function in zebrafish results in decreased Lymphoid enhancer facto...

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Autori principali: Ota, Satoshi, Ishitani, Shizuka, Shimizu, Nobuyuki, Matsumoto, Kunihiro, Itoh, Motoyuki, Ishitani, Tohru
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343332/
https://ncbi.nlm.nih.gov/pubmed/22373574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.46
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