Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing.

We have used a combination of highly specific protein phosphatase inhibitors and purified mammalian protein phosphatases to show that at least two separate Ser/Thr protein phosphatase activities are required for pre-mRNA splicing, but not for spliceosome assembly. Okadaic acid, tautomycin, and micro...

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Bibliographic Details
Main Authors: Mermoud, J E, Cohen, P, Lamond, A I
Format: Artigo
Language:Inglês
Published: 1992
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC334330/
https://ncbi.nlm.nih.gov/pubmed/1331983
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