Striatal Dopamine Transmission Is Subtly Modified in Human A53Tα-Synuclein Overexpressing Mice

Mutations in, or elevated dosage of, SNCA, the gene for α-synuclein (α-syn), cause familial Parkinson's disease (PD). Mouse lines overexpressing the mutant human A53Tα-syn may represent a model of early PD. They display progressive motor deficits, abnormal cellular accumulation of α-syn, and de...

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Bibliographic Details
Main Authors: Platt, Nicola J., Gispert, Suzana, Auburger, Georg, Cragg, Stephanie J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343082/
https://ncbi.nlm.nih.gov/pubmed/22570709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036397
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