A53T-Alpha-Synuclein Overexpression Impairs Dopamine Signaling and Striatal Synaptic Plasticity in Old Mice

BACKGROUND: Parkinson's disease (PD), the second most frequent neurodegenerative disorder at old age, can be caused by elevated expression or the A53T missense mutation of the presynaptic protein alpha-synuclein (SNCA). PD is characterized pathologically by the preferential vulnerability of the...

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Detalhes bibliográficos
Main Authors: Kurz, Alexander, Double, Kay L., Lastres-Becker, Isabel, Tozzi, Alessandro, Tantucci, Michela, Bockhart, Vanessa, Bonin, Michael, García-Arencibia, Moisés, Nuber, Silke, Schlaudraff, Falk, Liss, Birgit, Fernández-Ruiz, Javier, Gerlach, Manfred, Wüllner, Ullrich, Lüddens, Hartmut, Calabresi, Paolo, Auburger, Georg, Gispert, Suzana
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898885/
https://ncbi.nlm.nih.gov/pubmed/20628651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011464
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