Overexpression of the Catalytically Impaired Taspase1(T234V) or Taspase1(D233A) Variants Does Not Have a Dominant Negative Effect in T(4;11) Leukemia Cells

BACKGROUND: The chromosomal translocation t(4;11)(q21;q23) is associated with high-risk acute lymphoblastic leukemia of infants. The resulting AF4•MLL oncoprotein becomes activated by Taspase1 hydrolysis and is considered to promote oncogenic transcriptional activation. Hence, Taspase1’s proteolytic...

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Main Authors: Bier, Carolin, Hecht, Rouven, Kunst, Lena, Scheiding, Sabine, Wünsch, Désirée, Goesswein, Dorothée, Schneider, Günter, Krämer, Oliver H., Knauer, Shirley K., Stauber, Roland H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343046/
https://ncbi.nlm.nih.gov/pubmed/22570686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034142
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