Phase II trial of vorinostat and gemtuzumab ozogamicin as induction and post-remission therapy in older adults with previously untreated acute myeloid leukemia

Histone deacetylase inhibitors such as vorinostat enhance gemtuzumab ozogamicin efficacy in vitro. We, therefore, investigated vorinostat+gemtuzumab ozogamicin for adults aged 60 years and over with untreated acute myeloid leukemia. We stratified patients into 2 groups (group 1: patients aged ≥70 ye...

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Detalhes bibliográficos
Main Authors: Walter, Roland B., Medeiros, Bruno C., Powell, Bayard L., Schiffer, Charles A., Appelbaum, Frederick R., Estey, Elihu H.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2012
Assuntos:
Original Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342977/
https://ncbi.nlm.nih.gov/pubmed/22133771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.055822
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