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Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA.
Methylated DNA in vertebrates is associated with transcriptional repression and inactive chromatin. Two activities have been identified, MeCP1 and MeCP2, which bind specifically to DNA containing methyl-CpG pairs. In this report we characterize MeCP2. We show that it is more abundant than MeCP1, is...
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| Главные авторы: | , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
1992
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| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC334288/ https://ncbi.nlm.nih.gov/pubmed/1408825 |
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