Abnormal Intracellular Accumulation and Extracellular Aβ Deposition in Idiopathic and Dup15q11.2-q13 Autism Spectrum Disorders

BACKGROUND: It has been shown that amyloid ß (Aβ), a product of proteolytic cleavage of the amyloid β precursor protein (APP), accumulates in neuronal cytoplasm in non-affected individuals in a cell type–specific amount. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we found that the percent...

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Autori principali: Wegiel, Jerzy, Frackowiak, Janusz, Mazur-Kolecka, Bozena, Schanen, N. Carolyn, Cook, Edwin H., Sigman, Marian, Brown, W. Ted, Kuchna, Izabela, Wegiel, Jarek, Nowicki, Krzysztof, Imaki, Humi, Ma, Shuang Yong, Chauhan, Abha, Chauhan, Ved, Miller, David L., Mehta, Pankaj D., Flory, Michael, Cohen, Ira L., London, Eric, Reisberg, Barry, de Leon, Mony J., Wisniewski, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342283/
https://ncbi.nlm.nih.gov/pubmed/22567102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035414
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