Protocadherin-18 Is a Novel Differentiation Marker and an Inhibitory Signaling Receptor for CD8(+) Effector Memory T Cells

CD8(+) tumor infiltrating T cells (TIL) lack effector-phase functions due to defective proximal TCR-mediated signaling previously shown to result from inactivation of p56(lck) kinase. We identify a novel interacting partner for p56(lck) in nonlytic TIL, Protocadherin-18 (‘pcdh18’), and show that pcd...

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Detalhes bibliográficos
Main Authors: Vazquez-Cintron, Edwin J., Monu, Ngozi R., Burns, Jeremy C., Blum, Roy, Chen, Gregory, Lopez, Peter, Ma, Jennifer, Radoja, Sasa, Frey, Alan B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342238/
https://ncbi.nlm.nih.gov/pubmed/22567129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036101
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