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Protocadherin-18 Is a Novel Differentiation Marker and an Inhibitory Signaling Receptor for CD8(+) Effector Memory T Cells
CD8(+) tumor infiltrating T cells (TIL) lack effector-phase functions due to defective proximal TCR-mediated signaling previously shown to result from inactivation of p56(lck) kinase. We identify a novel interacting partner for p56(lck) in nonlytic TIL, Protocadherin-18 (‘pcdh18’), and show that pcd...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3342238/ https://ncbi.nlm.nih.gov/pubmed/22567129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036101 |
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