A Conserved Hydrophobic Patch on Vβ Domains Revealed by TCRβ Chain Crystal Structures: Implications for Pre-TCR Dimerization

The αβ T cell receptor (TCR) is a multimeric complex whose β chain plays a crucial role in thymocyte development as well as antigen recognition by mature T lymphocytes. We report here crystal structures of individual β subunits, termed N15β (Vβ5.2Dβ2Jβ2.6Cβ2) and N30β (Vβ13Dβ1Jβ1.1Cβ2), derived from...

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Bibliographische Detailangaben
Hauptverfasser: Zhou, Bo, Chen, Qiang, Mallis, Robert J., Zhang, Hongmin, Liu, Jin-huan, Reinherz, Ellis L., Wang, Jia-huai
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Research Foundation 2011
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341985/
https://ncbi.nlm.nih.gov/pubmed/22566796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2011.00005
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