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Molecular Mechanisms of Treg-Mediated T Cell Suppression

CD4(+)CD25(high)Foxp3(+) regulatory T cells (Tregs) can suppress other immune cells and, thus, are critical mediators of peripheral self-tolerance. On the one hand, Tregs avert autoimmune disease and allergies. On the other hand, Tregs can prevent immune reactions against tumors and pathogens. Despi...

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Main Authors: Schmidt, Angelika, Oberle, Nina, Krammer, Peter H.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Research Foundation 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341960/
https://ncbi.nlm.nih.gov/pubmed/22566933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2012.00051
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