Antisense probes targeted to an internal domain in U2 snRNP specifically inhibit the second step of pre-mRNA splicing.

Functional domains within the mammalian U2 snRNP particle that are required for pre-mRNA splicing have been analysed using antisense oligonucleotides. A comparison of the melting temperatures of duplexes formed between RNA and different types of antisense oligonucleotides has demonstrated that the m...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Barabino, S M, Sproat, B S, Lamond, A I
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 1992
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC334172/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1408748/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/20.17.4457
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