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A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes
Protein fiber formation is associated with diseases ranging from Alzheimer’s to type II diabetes. For many systems, including islet amyloid polypeptide (IAPP) from type II diabetes, fibrillogenesis can be catalyzed by lipid bilayers. Paradoxically, amyloid fibers are β-sheet rich while membrane stab...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3341621/ https://ncbi.nlm.nih.gov/pubmed/19778722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.08.013 |
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